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Study Examines Effects of Fish Oil Supplementation On Markers Of Inflammation In Chronic Kidney Disease Patients

by Anne Spencer | Jun 01, 2012

SAN FRANCISCO – The omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) present in fish oil are known to reduce inflammation throughout the body. According to the National Kidney Foundation, 26 million American adults have chronic kidney disease (CKD) and suffer from excessive production of pro-inflammatory cytokines, small proteins harmful to the body.

A study presented at American College of Sports Medicine’s 59th Annual Meeting in San Francisco concluded that fish oil supplementation has no effect on plasma pro-inflammatory cytokines TNF-α or IL-6, but does have an effect on IL-1β in non-dialysis CKD patients. The IL-1β cytokine is an important mediator for the anti-inflammatory response.

“The benefits of fish oil for an extensive range of health concerns and conditions are apparent,” said Erika Deike, Ph.D., lead investigator and assistant professor of exercise and sports science at Wayland Baptist University in Plainview, Texas. However, only a few studies have been done on the anti-inflammatory benefits for non-dialysis chronic kidney disease patients.”

Using a double blind, randomized, placebo-controlled experimental design, researchers followed 31 non-dialysis CKD patients for eight weeks while supplementing fish oil (2.4 grams/day) or placebo (safflower oil) in their diet. The study measured the effect on the following cytokines: IL-1β, IL-6, and TNF-α.

Statistical analysis revealed no difference in cytokines between groups at baseline. Additionally, no pretest differences existed between groups for age, weight, waist circumference, gender and ethnicity. However, the study discovered a significant difference on IL-1β in non-dialysis CKD patients. The IL-1β cytokine is an important mediator for the anti-inflammatory response.

Having an effect on IL-1β is beneficial as inflammation can play a significant role in cardiovascular disease in CKD patients.

The American College of Sports Medicine is the largest sports medicine and exercise science organization in the world. More than 45,000 international, national and regional members and certified professionals are dedicated to advancing and integrating scientific research to provide educational and practical applications of exercise science and sports medicine.

Contact for Erika Deike: 512-587-3606.

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The conclusions outlined in this news release are those of the researchers only, and should not be construed as an official statement of the American College of Sports Medicine.
The American College of Sports Medicine 59th Annual Meeting is going on now at the Moscone Center West.

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