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Conference Session Highlights

Keynote Lecture: Can Exercise Physiology Help Fill the Reductionist Gap?

Wed., Sept. 5, 2018  |  6:30 p.m.


Molecular reductionism includes an array of powerful tools that can provide insights in the behavior of DNA, proteins, signaling systems and cells.  However, these tools frequently fail to provide coherent and actionable insights into the emergent properties of whole animals including humans.  In this talk I will discuss how physiological insights from exercise might help bridge this gap.

Michael J. Joyner, M.D., FACSM
Mayo Clinic, Rochester

Meet the Expert Sessions Added to Conference Schedule

 
  • Thurs., Sept. 6

  • Fri., Sept. 7

  • Sat., Sept. 8

Debate:Are Exercise 'Mimetics' a Realistic Substitute for Exercise Training?

Thurs., Sept., 6  |  11:00 a.m. - 12:00 p.m.

Moderator: Frank Booth, FACSM

This debate will focus on data behind the use of exercise mimetics and whether exercise mimetics are a real substitute for exercise training. 

PRO: Exercise Mimetics Can Substitute for Exercise Training

Ron_Evans

Professor Ron Evans

  • PPARδ activates oxidative metabolism by mitochondria to alter metabolism and dramatically enhance running performance.
  • Drugs to PPARδ, known as exercise mimetics, target “metabolic gene networks” and efficiently increase endurance in absence of exercise

CON: Exercise Mimetics are NOT a Substitute for Exercise Training

John_Hawley

John Hawley

John Hawley tweeted (July 2018): “I’ll stick to training every day, as not sure any pill would ever give me the great feeling I get post-workout.”

Debate: Do Genetics Really Influence Exercise Capacity or Trainability?

Sat., Sept., 8  |  11:00 a.m. - 12:00 p.m.

Moderator: J. Timothy Lightfoot, FACSM

The interest in the genetic regulation of physiological traits extends to exercise responses and potential regulation of a variety of exercise phenotypes.  This debate will consider the data and conclusions underlying current thoughts regarding genetic regulation of exercise phenotypes.

PRO:  Genetics do Influence the Exercise Capacity and Trainability

Claude Bouchard, FACSM

Small effect size, biological redundancy and distributed regulation are pervasive in the biology of adaptation to exercise. They represent major challenges to overcome in the study of the genomic architecture and molecular physiology of cardiorespiratory fitness and its trainability but conceptual and technological advances continue to bring us closer to the finish line.

CON: Genetics do NOT Influence the Exercise Capacity and Trainability

Michael Joyner, FACSM 

 My position is that due to biological redundancy, molecular reductionism at the level of DNA variants is unlikely to provide extensive deterministic and actionable insights on the acute and chronic physiological responses to exercise. 

Program Topics

  • Cancer Prevention by Exercise: Role of Endocrine and Immune Function

  • Interactions between Mitochondrial Morphology and Turnover in Healthy and Diseased Skeletal Muscle

  • Understanding the Physiological Basis for Sex Differences in the Response to Exercise and Pathological Stimuli: A Role for Estrogen and Ovaries

  • Debate: Are Exercise Mimetics a Realistic Substitute for Exercise Training?

  • Debate: Do Genetics Really Influence Exercise Capacity or Trainability?

  • Recent Advances in Exercise and Arterial Stiffness

  • Metabolic Flexibility in Health and Disease

  • Exercise Pressor Reflex Function in Health and Disease

  • Exercise and Energy Restriction to Improve Health: The Crossroads of Energetics and Protein Turnover

  • The Role of Exosomes in Skeletal Muscle and Systemic Adaptation to Exercise

  • Men ? Women: Effects of Sex Hormones and Physical Activity on Vascular Function

  • Molecular Transducers of Exercise-induced Muscle Hypertrophy

  • How Exercise Promotes Brain Health in Aging

  • Is Mitochondrial Respiration a Limiting Factor of Oxidative Metabolism? An Integrated Approach to Exercise

The symposia lectures will be given by senior and emerging scientists and will provide a springboard for dynamic scientific exchanges. These sessions will include aspects of how advances in basic science lead to changes in practice.